既往学术研究推测，较较高的营养素D程度与1型癌症、炎病态肠病、近期病态疾病、类风湿关节炎等多种自身病态疾病病症涉及。为评估特发病态炎病态肌病（IIM）【包括多肌炎（PM）、皮肌炎（DM）、包涵体肌炎（IBM）、青少年DM（JDM）】病人对比肥胖IgG，其小鼠25（OH）营养素D的程度是否降较高，来自冰岛的卡罗林斯的卡学院风湿病学系的Payam Azali等人来进行了一项学术研究。学术研究结果发表于2013年4月的《风湿病学年刊》（Ann Rheum Dis）杂志上。学术研究推测，特发病态炎病态肌病病人小鼠营养素D程度较高。学术研究纳入了149则有IIM病人，以及290则有在病态别和小鼠样本采集月份各个方面相给定的肥胖IgG这群人，评估学术研究并不一定的小鼠25（OH）营养素D程度。营养素D程度在95%相符区间的OR值通过给定（有条件）逻辑重生模型来进行确定。使用鲍尔的卡尔-莫拉斯二氏筛选来进行四组间比较，P值＜0.05被认为有意义。IIM病人小鼠25（OH）营养素D程度较肥胖IgG这群人明显降较高【均值39（10-168）nmol/l vs 68（19-197）nmol/l；P=0.0001】。肌炎各亚四组间的营养素D程度无显著分野。如将营养素D程度分为缺失（＜50nmol/l）、不足（50-74nmol/l）和正常人（≥75nmol/l）三种层次，那么绝大多肌炎病人正处于缺失四组（PM68%、DMA65%、IBM53%），相比之下，肥胖IgG中只有60则有（21%）正处于缺失四组。IIM病人营养素D程度缺失相比于正常人的OR值为17.7（95%CI 8.1-38.6），营养素D程度不足相比于正常人的OR值为2.4（95%CI 1.2-4.7）。学术研究推测，如同其他一些自身病态疾病病症一样，大多IIM病人的小鼠营养素D程度降较高，其可被视为成年肌炎发病的危险心理因素。与肌病涉及的拓展写作：
病则有报告：氟醇致药物病态骨骼肌病一则有JAMA：骨骼肌纤维化是扩张型骨骼肌病病人频发心源病态猝死的独立预测心理因素JAMA：增强心脏MR可缓解正因如此骨骼肌病全面性程度EUR HEART J：NT-proBNP合理预测肥厚型骨骼肌病病人肾功能HEART RHYTHM :致心律失常病态骨骼肌病病人或存在骨骼肌信号传导失常Circulation：肥厚病态骨骼肌病遗传外显百余人清查格外多信息商量点击：有关肌病格外多资讯Low serum levels of vitamin D in idiopathic inflammatory myopathies.OBJECTIVESTo evaluate serum levels of 25(OH) vitamin D in patients with idiopathic inflammatory myopathies (IIM) (polymyositis (PM), dermatomyosistis (DM), inclusion body myositis (IBM) and juvenile DM (JDM)) and to compare these with healthy controls.METHODSSerum samples from 149 patients with IIM and 290 healthy controls matched for gender and the month of blood sampling were ysed for 25(OH) vitamin D. ORs for vitamin D classes with 95% CI were calculated using a matched (conditional) logistic regression model. Groups were compared by the Kruskal-Wallis test and p values <0.05 were considered significant.RESULTSPatients with IIM had significantly lower serum levels of 25(OH) vitamin D than healthy controls (median 39 (10-168) nmol/l vs 68 (19-197) nmol/l; p=0.0001). There was no significant difference in vitamin D levels between the myositis subgroups. When vitamin D levels were subclassified into deficient (<50 nmol/l), insufficient (50-74 nmol/l) and normal (≥75 nmol/l), most of the patients with PM (68%), DM (65%) and IBM (53%) had deficient levels compared with only 60 (21%) healthy individuals. In patients with IIM the OR for deficient versus normal was 17.7 (95% CI 8.1 to 38.6) and the OR for insufficient versus normal was 2.4 (95% CI 1.2 to 4.7).CONCLUSIONSLow serum levels of vitamin D were found in most patients with IIM and may confer a risk factor for developing myositis, similar to some other autoimmune diseases.
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